Uniklinikum Tübingen

Andrea Kübler

- Assistant Professor  (Privatdozentin) -

Email:

andrea.kuebler(at)uni-tuebingen.de

Phone:

+49-7071-29-75997

Fax:

+49-7071-29-5956

Mail:

PD Dr. Andrea Kübler

Institute of Medical Psychology and Behavioral Neurobiology

Eberhard-Karls-University

Gartenstr. 29

D-72074 Tübingen

Sprechstunde



donnerstags 14.00-16.00 Uhr nach Vereinbarung

 

Lehre im SS07



Kurs Medizinische Psychologie: s. Aushang und Lehre des Instituts im Internet, Gartenstr., Beginn 23.04.07 (für Studierende der Medizin)

Seminar Medizinische Psychologie (Projekt): "Lebensqualität - ein individuelles und variables Konstrukt (siehe Lehrseite des Instituts) (für Studierende der Medizin). Aushänge und Ankündigungen auf der Institutshomepage unbedingt beachten!

Seminar: Sucht - Entstehung, Aufrechterhaltung und Therapie: für Studierende der Psychologie  und Medizin. Dienstags, 11-13.00 Uhr. Anmeldung erforderlich: Medizin direkt per email; Psychologie: über Seminaranmeldung bei Herrn Hautzinger.

Diplomarbeiten



  • Aufmerksamkeitsverzerrung als Prädiktor für Alkoholismus
  • Formale Aspekte von Träumen; Untersuchungen zur Sprache im Traum. Wie häufig wird gesprochen? Ist die Sprache sinnvoll? Findet Konversation statt? Ist die Sprache nur gedanklich oder wird tatsächlich gesprochen?
  • Verschiedene Themen im Bereich Gehirn-Computer Schnittstellen

 

 

Current Research



I am working as Assistant Professor at the Institute of Medical Psychology and Behavioural Neurobiology, University of Tübingen

 

Research :

(1)

Cortical slow potential and mu-rhythm neurofeedback (visual, auditory) as a communication tool for locked-in patients ("Thought Translation Device, BCI2000"). Event-related potentials (P300) for communication and diagnosis in disorders of consciousness.  Development of a flexible general purpose brain-computer interface (BCI) system that can incorporate any of the relevant signals, analyses, and operating formats and can be configured for laboratory or clinical needs and to use the system to compare, contrast, and combine relevant brain signals and signal processing options during BCI operation and thereby develop a standard protocol for applying BCI technology to the needs of individual users. The system is applied and documented to address specific communication needs of people with severe motor disabilities and show that BCI technology is both useful to and actually used by these individuals.

(2)

Assessment of depression, quality of life, and coping strategies in locked-in patients. Executive functioning in patients with neurodegenerative diseases.
Ethical considerations on life sustaining treatment and the withdrawal thereof in non-responsive patients.

(3)

Attention, sleep, dreaming and consciousness in healthy individuals, locked-in patients and patients with disorders of consciousness.  Polysomnography is conducted in the hospital or at home in patients with neurological diseases (amyotrophic lateral sclerosis).  Day time attention is assessed and in further studies 24 hour recordings will be conducted to investigate the course of attention and sleep profile in locked-in patients.
Formal aspects of REM sleep dreams are assessed in healthy subjects. Specifically emotions and speech.

(4)

I nvestigation of the effects of drug abuse (specifically cocaine use) on executive functioning in addicts using functional Magnetic Resonance Imaging. Cocaine addicts perform a number of high-level cognitive tasks before and after injection of cocaine while their brains are being imaged. The goal is to observe how cocaine use might disrupt normal cognitive function thereby providing an insight into the psychological effects of drug use and into alterations (psychological and neurological) arising from drug use that may dispose the addict to further use.
Cue-reactivity in social drinkers and inhibitory control in reduced emotional reactivity such as in individuals with antisocial personality disorders.

 

 

Selection of Publications



  • Kübler, A., Dixon, V., & Garavan, H. (2006). Automaticity and re-establishment of executive control ? an fMRI study. Journal of Cognitive Neuroscience, 18, 1331-1342.

  • Kübler, A., Mushahwar, V., Hochberg, L. R., & Donoghue, J. P. (2006). BCI Meeting 2005 - Workshop on Clinical Issues and Applications. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 14, 131-134.

  • Sellers, E.W., Kübler, A., Donchin, E (2006). Brain computer interface research at the University of South Florida Cognitive Psychophysiology Laboratory: The P300 Speller. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 14, 221-224

  • Kübler, A., Weber, C., & Birbaumer, N. (2006). Locked-in - freigegeben für den Tod. Wenn nur Denken und Fühlen bleiben - Neuroethik des Eingeschlossenseins. Zeitschrift für Medizinische Ethik, 52, 57-70.

  • Kübler, A., & Neumann, N. (2005). Brain-computer interfaces - the key for the conscious brain locked into a paralysed body. Progress in Brain Research, 150, 513-525.

  • Kübler, A., Winter, S., Ludolph, A., Hautzinger, M. & Birbaumer, N. (2005). Severity of depressive symptoms and quality of life in patients with amyotrophic lateral sclerosis. Neurorehabilitation and Neural Repair, 19, 1-12..

  • Kübler, A., Nijboer, F., Mellinger, J., Vaughan, T. M., Pawelzik, H., Schalk, G., McFarland, D. J., Birbaumer, N., & Wolpaw, J. R. (2005). Patients with ALS can use sensorimotor rhythms to operate a brain-computer interface. Neurology, 64, 1775-7.

  • Kübler, A., Murphy, K. & Garavan, H. (2005). Cocaine dependence and attention switching within and between verbal and visuospatial working memory. European Journal of Neuroscience, 21, 1984-92.

  • Kübler, A., Winter, S., Kaiser, J., Birbaumer, N. & Hautzinger, M. (2005). Ein Fragebogen zur Messung von Depression bei degenerativen neurologischen Erkrankungen (amyotrophe Lateralsklerose) [An inventory to measure depression in neurodegenerative diseases (amyotrophic lateral sclerosis)]. Zeitschrift für Klinische Psychologie und Psychotherapie, 34 (1), 19-26.

  • Kübler, A., Neumann, N., Wilhelm, B., Hinterberger, T. & Birbaumer, N. (2004) Predictability of brain-computer communication. Journal of Psychophysiology, 18, 121-129.

  • Hinterberger, T., Neumann, N., Pham, M., Kübler, A., Grether, A., Hofmayer, N., Wilhelm, B., Flor, H. & Birbaumer, N. (2004) A multimodal brain-based feedback and communication system. Experimental Brain Research , 154, 521-526.

  • Neumann, N., Hinterberger, T., Kaiser, J., Leins, U., Birbaumer, N. & Kübler, A . (2004) Automatic processing of self-regulation of slow cortical potentials: evidence from brain-computer communication in paralysed patients. Clinical Neurophysiology , 115, 628-635.

  • Kübler, A., Murphy, K., Kaufman, J., Stein, E.A., & Garavan, H. (2003). Co-ordination within and between verbal and visuospatial working memory: network modulation and anterior frontal recruitment. NeuroImage, 20, 1298-1308.

  • Neumann, N. & Kübler, A. (2003). Training locked-in patients: a challenge for the use of brain-computer interfaces. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 11 , 169-172.

  • Neumann, N., Kübler, A., Kaiser, J., Hinterberger, T., & Birbaumer, N (2003). Conscious perception of brain states: mental strategies for brain-computer communication. Neuropsychologia, 41 , 1028-1036.

  • Kotchoubey, B., Kübler, A., Strehl, U., Flor, H., & Birbaumer, N. (2002). Can humans perceive their brains? Consciousness and Cognition, 11, 98-113.

  • Kübler, A., Kotchoubey, B., Kaiser, J., Wolpaw, J., & Birbaumer, N. (2001). Brain-computer communication: unlocking the locked-in. Psychological Bulletin, 127, 358-375.

  • Kübler, A., Neumann, N., Kaiser, J., Kotchoubey, B., Hinterberger, T., & Birbaumer, N. (2001). Brain-computer communication: Self-regulation of slow cortical potentials for verbal communication. Archives of Physical Medicine and Rehabilitation . 82 , 1533-9.

  • Birbaumer N, Ghanayim N, Hinterberger T, Iversen I, Kotchoubey B, Kübler A, Perelmouter J, Taub E, & Flor H (1999). A spelling device for the paralysed. Nature , 398 , 297-98.

  • Rieger, A., Lutz, A. and Hampp, R. (1992). Compartimentation of soluble carbohydrates, of starch and of malate in motor organs (pulvini) and other parts of Phaseolus coccineus L. leaves. Planta 187: 95-102.

 

 

 

Teaching and supervision



Teaching: Medical psychology for medical students. Div. seminars in psychology (see section on teachin in summer term).

Supervision: undergraduate and postgraduate students of medicine, psychology and computer science (internships, diploma (master) thesis, PhD thesis).

 

Education



1970 - 1983:

School education

1983 - 1990:

University of Stuttgart, University of Würzburg and University of Tübingen, Institute of Physiological Ecology, Germany. Diploma of Biology (equivalent to Master of Science).

Dissertation: Untersuchungen zur Kohlenhydratverteilung im Laminargelenk und anderen Blattgeweben von Phaseolus coccineus L . während der circadianen Blattbewegung im tagesperiodischen Licht-Dunkelwechsel. (Investigations of the distribution of carbohydrates in motor organs (pulvini) and other leaf tissue of Phaseolus coccineus L. during circadian leaf movement in the daily light-dark variations.)

February 2000:

Doctorate of the Natural Sciences ( doctor rerum naturum equivalent to PhD)

1996-2001:

University of Tübingen, Institute of Psychology, Germany. Diploma of Psychology (equivalent to Master of Science).

Dissertation: Entwicklung eines Fragebogens zur Messung des Schweregrades depressiver Symptomatik bei Patienten mit amyotropher Lateralsklerose (Development of a Depression Inventory for patients with amyotrophic lateral sclerosis).

December 2005

Habilitation at the Faculty of Computational and Cognitive Sciences; venia legendi for Psychology

 

 

Experiences and previous positions



1988?1991:

Research assistant at the Institute of Physiological Ecology of Plants, University of Tübingen, Germany, department chairman: Prof. R. Hampp.

1991-1995:

Lector at publishers: Ulmer, Stuttgart and Franckh-Kosmos, Stuttgart, Germany.

1992-1995:

Manager of the Green Party, region Stuttgart.

1994-1997:

Member of the city council, Stuttgart.

1996-Sept. 2000:

Senior research assistant at the Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, department chairman: Prof. Birbaumer.

Oct. 2000-Oct. 2001:

Assistant professor at the Institute of Medical Psychology and Behavioural Neurobiology, University of Tübingen, department chairman:
Prof. Dr. Niels Birbaumer.

Nov. 2001-Oct. 2003:

Research Fellow at the Department of Psychology, Trinity College Dublin, department chairman: Prof. Dr. Ian Robertson.